Effect of interleukin-1 receptor antagonist on concanavalin A response of peripheral blood mononuclear cells from newborn calves
2001
Yamanaka, H. (Rakuno Gakuen Univ., Ebetsu, Hokkaido (Japan)) | Katagiri, Y. | Domi, M. | Hagiwara, K. | Kirisawa, R. | Iwai, H.
The coexistence of interleukin (IL)-1 v with IL-1 receptor antagonist (ra) in bovine colostrum and the possibility of simultaneous transfer of these cytokines to neonates via colostrum have been demonstrated. In the present study, we investigated the effect of IL-lra on the mitogenic response of calf peripheral blood mononuclear cells (PBMC) stimulated by concanavalin A (ConA), which was mediated by IL-1. Pretreatment of PBMC with recombinant bovine (rb) IL-lra alone significantly suppressed the proliferation of ConA-stimulated cells. However, in the presence of rbIL-1 v, the suppressive activity of rblL-lra was counteracted. These results suggest that coexistence of IL-lra with IL-1 in colostrum may have no effect on the activation of the neonatal immune system by IL-1 v.
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