Effects of marbofloxacin on the activity of macrophages and T and B cells in non-infected and E. coli-infected mice
Szczypka, M. | Gaweda, B. | Obminska-Mrukowicz, B.(Wroclaw Agricultural University (Poland). Dept. of Biochemistry Pharmacology and Toxicology)
The studies were conducted on non-infected and E. coli-infected mice treated with marbofloxacin (Marbocyl 10 percent inj.) administered intramusculary five times at 24-h intervals at a dose of 2 mg/kg. It has been found that marbofloxacin augments the percentage of phagocyting cells in non-infected mice, but does not change the number of phagocytized bacteria. However, marbofloxacin impaires the killing activity of peritoneal macrophages in non-infected mice (decreased nitric oxide production) and E. coli-infected mice (decreased percentage of NBT-positive cells). Moreover, marbofloxacin enhances the synthesis and release of interleukin-1 (IL-1), both in non-infected and E. coli-infected mice. The administration of marbofloxacin has also been found to increase the percentage of immature CD4+CD8+ thymic cells and to decrease the percentage of double-negative (CD4-CD8-) and single-positive (CD4+ and CD8+) thymocytes. Administration of marbofloxacin does not change the percentage of T and B splenocytes and mesenteric lymph node cells in non-infected and E. coli-infected mice
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