Renal Precursor Cell Transplantation Using Biodegradable Polymer Scaffolds
2005
Kim, S.S. (Hanyang University, Seoul, Republic of Korea) | Park, H.J. (Sungkyunkwan University, Seoul, Republic of Korea) | Han, J.H. (Sungkyunkwan University, Seoul, Republic of Korea) | Park, M.S. (Hanyang University, Seoul, Republic of Korea) | Park, M.H. (Hanyang University, Seoul, Republic of Korea) | Song, K.W. (Hanyang University, Seoul, Republic of Korea) | Joo, K.J. (Sungkyunkwan University, Seoul, Republic of Korea) | Choi, C.Y. (Seoul National University, Seoul, Republic of Korea) | Kim, B.S. (Hanyang University, Seoul, Republic of Korea), E-mail: [email protected]
End-stage renal disease is a fatal and devastating disease that is caused by progressive and irreversible loss of functioning nephrons in the kidney. Dialysis and renal transplantation are the common treatment at present, but these treatments have severe limitations. The present study investigated the possibility of reconstructing renal tissues by transplantation of renal precursor cells to replace the current treatments for end-stage renal disease. Embryonic renal precursor cells, freshly isolated from metanephroi of rat fetus at day 15 post-gestation, were seeded on biodegradable polymer scaffolds and transplanted into peritoneal cavities of athymic mice for three weeks.
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