Safety Pharmacology of CJ-11555
2004
Choi, J.M. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), E-mail: [email protected] | Rowton, S (Covance Laboratories, North Yorkshire, England) | Lee, S.H. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea) | Kim, I.H. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea) | Park, J.E. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea) | Noh, H.J. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of KoreaRnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea) | Kim, T.R. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea) | Kim, Y.H. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea) | Kim, J.W. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea) | Jang, J.H (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea) | Kim, D.Y (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea) | Esmail A (Covance Laboratories, North Yorkshire, England) | Trepakova Elena, S (Covance Laboratories, North Yorkshire, England)
Safety pharmacological properties of CJ-11555, an anti-cirrhotic agent, were investigated in experimental animals and in vitro test system. CJ-11555 had no effects on normal body temperature in rats, motor coordination, chemoshock induced by pentetrazol, electric shock induced by electric shocker and writhing syndromes in mice at dose levels of 100, 300 and 1,000 mg/kg. CJ-11555 inhibited intestinal activity and prolonged hexobarbital-induced sleeping time in mice at the dose level of 1,000 mg/kg. CJ-11555 affected on general activity and behaviour tests in SD rats, such as lacrimation, ptosis, piloerection, decreased body tone, abnormal dispersion within the cage, diarrhoea, red colored faeces, slight hypothermia and decreased grooming, at the dose level of 1,000 mg/kg in rats.
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