Toxicity of Aristolochiae radix in F344 rats
2005
Kim, C.Y. (Korea Institute of Toxicology, Daejeon, Republic of Korea) | Yang, K.H. (National Institute of Toxicological Research, KFDA, Seoul, Republic of Korea) | Kim, Y.B. (Korea Institute of Toxicology, Daejeon, Republic of Korea) | Yang, B.C. (Korea Institute of Toxicology, Daejeon, Republic of Korea) | Lee, J.H. (Korea Institute of Toxicology, Daejeon, Republic of Korea) | Chung, M.K. (Korea Institute of Toxicology, Daejeon, Republic of Korea) | Han, S.S. (Korea Institute of Toxicology, Daejeon, Republic of Korea), E-mail: sshan@kitox.re.kr | Kang, B.H. (Korea Institute of Toxicology, Daejeon, Republic of Korea) | Jang, D.D. (National Institute of Toxicological Research, KFDA, Seoul, Republic of Korea)
13-week orally repeated dose toxicity was investigated to ascertain the toxic effects of Aristolochiae radix in F344 rats at dose levels of 0, 1 (0.003 AA, aristolochic acid, mg/kg), 5 (0.014 AA mg/kg), 25 (0.068 AA mg/kg), 125 (0.34 AA mg/kg), and 500 mg/kg (AA 1.36 mg/kg). No mortalities were found in any of the dose groups including vehicle control groups of both sexes during the study period. Hematologic and serum biochemical examinations revealed no changes related to the test item in any of the dose groups of both sexes. However, gross findings at necropsy implicated thickening of the stomach wall.
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