Antioxidant Property of Genistein: Inhibitory Effect on HOCl Induced Protein Degradation, DNA Cleavage, and Cell Death
2005
Choi, J.M. (Yonsei University, Seoul, Republic of Korea) | Ryu, H.J. (Asan Medical Center, Seoul, Republic of Korea) | Chung, J.H. (World Research Corporation, Seoul, Republic of Korea) | Park, J.C. (Yonsei University, Seoul, Republic of Korea) | Hwang, J.K. (Yonsei University, Seoul, Republic of Korea) | Shin, D.B. (Cheju National University, Cheju, Republic of Korea) | Lee, S.K. (Yonsei University, Seoul, Republic of Korea) | Ryang, R. (Yonsei University, Seoul, Republic of Korea), E-mail: yangr@yonsei.ac.kr
The aim of this study was to investigate the in vitro antioxidant profiles of genistein and other isoflavonoids. The reactivity of genistein towards stable radical and reactive oxygen species including ABTS+, O₂-, H₂O₂ and HOCl has been investigated, and the effects were compared with other isoflavonoids and antioxidants. All the tested isoflavonoids showed remarkable ABTS+ scavenging activity and genistein was more potent than BHT and ascorbic acid. Genistein was more effective in scavenging hypochlorous acid than superoxide and hydrogen peroxide.
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