Effect of Dietary Docosahexaenoic Acid on Maze-learning Ability in Aged Mice Fed N-3 Fatty Acid Deficient Diet
2005
Lim, S.Y. (Korea Maritime University, Busan, Republic of Korea), E-mail: [email protected] | Suzuki, Hiramitsu (National Food Research Institute, Kannondai, Tsukuba, Ibaraki, Japan)
The effect of docosahexaenoic acid (DHA) on maze-learning ability in aged mice was investigated. Aged mice fed a diet deficient in n-3 fatty acid received a semi-purified diet of 0.5, 1 and 2% DHA-ethyl ester (DHA-EE) for 4 months. Maze-learning ability was assessed at 3 months after the start of the experiment. The time required to reach the maze exit and the number of times that a mouse strayed into blind alleys in the maze were measured in 3 trials conducted at 4-day intervals.
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