Egg production with lowering the n-6/n-3 ratio of fatty acids by scrap rice and perilla seed, and suppression of allergic hyper-reactivity by that in rats
2004
Sawada, H.(Fukui-ken, Livestock Hygiene Service Center (Japan)) | Sawada, Y. | Yamaguchi, R. | Katoh, T. | Tatematsu, K. | Okuyama, H.
Suffering from a disease like allergic hyper-reactivity, and myocardial infarction have been increasing rapidly along with increase in linoleate (LA,n-6) intake. LA is converted to aracbidonic acid (AA,n-6), a precursor of inflammatory mediators, and we interpreted that over- and unbalanced productions of n-6 mediators form a major basis for allergic hyper-reactivity. N-3 fatty acids and their metabolites compete with the LA cascade at several steps of enzymes and receptors, thereby serving for suppression of the allergic hyper-reactivity through decreased productions of n-6 lipid mediators. We have evaluated foods with low n-6/n-3 ratios for their ability to suppress lipid mediator productions in animals and presented evidence that a egg aiming at lowering a n-6/n-3 ratio is effective for the treatment of atopic dermatitis. Linoleic acids composition (7%)of eggs produced with feeding of scrap rice replaced for corn in the conventional diet for hens was lower than that in the conventional group (11.9%) during the six weeks. A n-6/n-3 ratio lowered to 2.4, whereas that in the conventional group was 3.9. Linoleic acids composition of eggs produced with scrap rice replaced for corn in the conventional diet for hens lowered slightly. When perilla seed was added to a scrap rice-based conventional diet, the absolute values of both LA and AA in eggs were decreased. In conclusion, the n-6/n-3 ratios in egg lipids in addition of perilla seed, 0%, 2.5%, and 10% were 3.5, 1.6 and 0.9 respectively. On the other hand, a n-6/n-3 ratio in egg lipids produced with a corn-based conventional diets was 5.8. The eggs produced with such dietary manipulations have been proven to be effective on reducing significantly LT B4 production in rats.
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