Inhibitory effects of a water-soluble extract from culture medium of Ganoderma lucidum (Rei-shi) mycelia on postprandial blood glucose elevation in mice and additional effect with alpha-glucosidase inhibitor
2007
Usui, T.(Josai Univ., Sakado, Saitama (Japan)) | Okazaki, M. | Kamiuchi, S. | Suzuki, F. | Iizuka, H. | Hibino, Y.
The water-soluble extract (WER) was prepared from the culture medium of Ganoderma lucidum (Rei-shi), which was composed of bagasse and rice bran. WER had suppressive effects on postprandial blood glucose elevation using sugar tolerance tests in mice. Oral administration of WER (1 g/kg), which did not affect fasting blood glucose, showed significant suppression on the increase of blood glucose levels after loading of maltose (21% decrease in AUC) or starch (15% decrease in AUC), compared to the control mice. In vitro study showed that WER inhibited maltase, sucrase and alpha-amylase in concentration-dependent manner. These results suggest that WER has a glucose-lowering effect after loading sugar, which may be based on inhibition of the activity of saccharide hydrolyzing enzymes. Moreover, in the present study, we aimed to examine the effects of WER on voglibose. WER did not enhance the inhibitory effects of alpha-glucosidase on voglibose (1 microg/mL), nor on voglibose (0.035 microg/mL). In addition, oral administration of voglibose (0.1 mg/kg) with WER (1 g/kg) resulted in no significant change in AUC. These results indicate that concomitant intake of voglibose with WER may not cause additive effects on postprandial blood glucose elevation by food-drug interaction.
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