Newly synthesized oleylgingerol and oleylshogaol activate TRPV1 ion channels
2007
Morita, A.(Shizuoka Univ. (Japan)) | Iwasaki, Y. | Kobata, K. | Yokogoshi, H. | Watanabe, T.
The oleyl moiety in vanilloids is important in activating vanilloid receptor 1 (TRPV1), but there was no ingredient of ginger containing the oleyl moiety in the natural form. We synthesized oleylgingerol and oleylshogaol and then evaluated their potential to activate a rat TRPV1 channel. Oleylgingerol is a stronger TRPV1 agonist than natural gingerols, but oleylshogaol is a weaker agonist than natural shogaols. The difference in structure between oleylgingerol and oleylshogaol is only the hydroxy group at carbon-5. This hydroxy group might have an important role in activating a TRPV1 channel.
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