Inhibition of 17alpha-hydroxylase/C17,20-lyase (CYP17) from rat testis by green tea [Camellia sinensis] catechins and black tea theaflavins
2007
Kimura, K.(Iwate Univ., Morioka (Japan). Faculty of Agriculture) | Itakura, Y. | Goto, R. | Tojima, M. | Egawa, N. | Yoshihama, M.
In the course of screening for 17alpha-hydroxylase/Csub(17,20)-lyase inhibitors from food ingredients, the methanol soluble fraction of green tea and black tea, which were expected to be rich in catechin and theaflavin content, showed potent inhibitory activity. (-)-Epigallocathechin gallate and theaflavin 3-O-gallate with a pirogallol moiety significantly inhibited Csub(17,20)-lyase activity on ICsub(50) values of 24.5 microM and 11.5 microM respectively. They had potent cytotoxicity against human prostate cancer LNCaP cells (ICsub(50)=28.1 microM and 37.4 microM).
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