Effect of Rhodiola Sachalinensis Administration and Endurance Exercise on Insulin Sensitivity and Expression of Proteins Related with Glucose Transport in Skeletal Muscle of Obese Zucker Rat
2006
Oh, J.K. (Korea National Sport University, Seoul, Republic of Korea), E-mail: [email protected] | Shin, Y.O. (Korea National Sport University, Seoul, Republic of Korea) | Jung, H.J. (Korea National Sport University, Seoul, Republic of Korea) | Lee, J.E. (Korea National Sport University, Seoul, Republic of Korea)
Peripheral insulin resistance in obese/type Ⅱ diabetes animals results from an impairment of insulin-stimulated glucose uptake into skeletal muscle. Insulin stimulate the translocation of GLUT4 from intracellular location to the plasma membrane. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) is implicated in mediation of fusion of GLUT4-containing vesicle with the plasma membrane. Present study investigated regulatory effects of Rhodiola sachalinensis administration and exercise training on the expression of GLUT4 protein and SNAREs protein in skeletal muscles of obese Zucker rats.
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