The Cytotoxicity of Artemisia fukudo Extracts Against HL-60 Cells
2007
Kim, K.N. (Jeju Hi-Tech Industry Development Institute, Jeju, Republic of Korea) | Lee, J.A. (Jeju Hi-Tech Industry Development Institute, Jeju, Republic of Korea) | Yoon, W.J. (Jeju Hi-Tech Industry Development Institute, Jeju, Republic of Korea) | Kim, J.Y. (Jeju Hi-Tech Industry Development Institute, Jeju, Republic of Korea) | Song, G.P. (Jeju Hi-Tech Industry Development Institute, Jeju, Republic of Korea) | Park, S.Y. (Jeju Hi-Tech Industry Development Institute, Jeju, Republic of Korea), E-mail: [email protected]
The present study describes the cytotoxic effect of Artemisia fukudo extracts. The extract from A. fukudo by 80% ethanol was fractionated with n-hexane, dichloromethane, ethylacetate, and butanol in serial. The cytotoxicity of A. fukudo extracts was examined for its effect on the growth of HL-60 cells by the colorimetric 3-(4,5-dimethylthiazol)-2,5-diphenyltetrazolium bromide (MTT) assay. In addition, we used the HL-60 cells to see what effects the A. fukudo extracts will have on apoptosis of cancer cells. We checked the cell activity, cell morphologic changes, DNA fragmentation, and DNA content after 24 hr incubation with administering 25 ㎍/mL of the A. fukudo extracts.
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