Fluoride toxicity on the histopathological aspects of liver in the Cirrhinus mrigala

Shoukat, S.; Riaz, S. . Dept. of Microbiology and Molecular Genetics; Mughal, M.S.

Fluoride toxicity on the histopathological aspects of liver in the Cirrhinus mrigala

2007

Shoukat, S. (Government Coll. Univ., Lahore (Pakistan)) | Riaz, S. (Punjab Univ., Lahore (Pakistan). Dept. of Microbiology and Molecular Genetics) | Mughal, M.S. (Government Coll. Univ., Lahore (Pakistan))

In the present research work, effect of fluoride on the liver of fish, Cirrhinus mrigala was observed. Fish were acclimatized under laboratory conditions and exposed to different concentrations of sodium fluoride from 200 to 1200 mg/L for 96 hours to find out the LC50 that was about 312 mg/L. The experiment was conducted in two phases, acute and sub acute. In acute phase, 4 groups were made with 50, 70 and 90 mg/L of sodium fluoride concentration. For sub acute phase, 7 groups were made having 1, 2, 4, 8. 16 and 32 days expose the fluoride concentration as 25 mg/L. In all phases control was run parallel to each group. In the all above exposures, it was concluded that various doses of fluoride showed significant, moderately and highly significant histopathological changes in the liver such as atrophy, pyknotic nuclei, necrosis, congestion, degeneration, disintegration, infiltration of lymphocytes and destruction of hepatocytes. These changes were time and close dependent.

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