Monitoring of mitotic index and frequency of micronuclei in evaluation of genotoxic potential of fumagillin (dicyclohexylamine) in vivo
2006
Stevanovic, J., Faculty of Veterinary Medicine, Belgrade (Serbia) | Stanimirovic, Z., Faculty of Veterinary Medicine, Belgrade (Serbia) | Pejin, I.I., Faculty of Veterinary Medicine, Belgrade (Serbia) | Lazarevic, M., Faculty of Veterinary Medicine, Belgrade (Serbia)
Fumagillin (dicyclohexylamine) is a natural antibiotic, secreted by Aspergillus fumigatus. It is used in veterinary medicine. In this study, the genotoxicity of fumagillin was evaluated in mouse bone marrow cells using the mitotic index (MI) and micronucleus (MN) assay. The results suggest that fumagillin (dicyclohexylamine) has an antiproliferative and genotoxic potential in mammal in vivo test.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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