Antioxidant status in canine cancer patients
2008
Plavec, T., University of Ljubljana, Ljubljana (Slovenia). Veterinary Faculty | Nemec, S.A., University of Ljubljana, Ljubljana (Slovenia). Veterinary Faculty | Butinar, J., Animal Hospital, Postojna (Slovenia) | Tozon, N., University of Ljubljana, Ljubljana (Slovenia). Veterinary Faculty | Prezelj, M., University Medical Centre, Ljubljana (Slovenia). Veterinary Faculty | Kandel, B., Holheim Veterinary Hospital, Holheim am Taunus (Germany) | Kessler, M., Holheim Veterinary Hospital, Holheim am Taunus (Germany)
The results of the study showed a significant increase of catalase (CAT) activity in tumour groups except in the patients with nasal tumours. Superoxide dismutase (SOD) activity increased significantly in malignant melanoma, mast cell tumours, multicentral lymphoma and oral fibrosarcoma patients. Appendicular osteosarcoma and multicentral lymphoma patients showed significantly increased levels of glutathione peroxidase (GPX) and total antioxidant capacity (TAC), respectively. Activities of catalase (CAT) and superoxide dismutase (SOD) were significantly higher comparing the all investigated cancer patients with healthy dogs. Tumour patients showed significantly lower levels of haemoglobin when compared to healthy dogs. The increase of antioxidant enzyme activities and total antioxidant capacity (TAC) in the these animals suggest the activation of antioxidant defence mechanisms in different cancer diseases.
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