Biological availability of oxytetracycline in sheep after Tetraxyl L.A. and Alamycin L.A. application
2005
Neuschl, J.(University of Veterinary Medicine, Kosice (Slovak Republic) | Nagy, J. | Popelka, P | Sokol, J. | Marcincak, S.
Blood serum concentrations and biological half-life of oxytetracycline (OTC) after long action preparations were investigated in adult sheep of the Slovak merino breed. Contemporarily their local tolerance has also been observed. In the first group (N=6) oxytetracycline was administered in the form of preparation Tetraxyl L. A. inj. a.u.v. (Biotika, Slovenska Lupca, Slovak Republic) and in the second group (N=5) in form of preparations Alamycin L.A. inj. a.u.v. (Norbook Laboratories Limited, North Ireland). Oxytetracycline was administered intramuscularly at a single dose of 20 mg per kg of live weight. The blood serum concentrations of OTC were studied in the intervals of 1, 3, 6, 24 hours and 2, 3, 4 and 5 days after single administration of preparations. OTC has been determined by high HPLC chromatography. Therapeutically concentrations of OTC (above 0.5 micro g per ml) produced by Tetraxyl were detected in 74 hours in and after Alamycin administration in 67--68 hours. Detectable concentrations of OTC (under MIC) of Tetraxyl (0.28 micro g per ml) and Alamycin (0.14 micro g per ml) were recorded in 96 hours. On the 5 day all samples, in both groups, were negative. On the basis of our results was concluded that in selected pharmaceutically parameters and also in local tolerance Tetraxyl L.A. is more favourable in comparison with Alamycin L.A.
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