Comparative studies on the anthelmintic efficacy of the combination oxantel pamoate, pyrantel pamoate and praziquantel and the combination pyrantel pamoat and praziquantel against hookworm and whipworm infection in dogs
2005
Soontorn Kiartmanakul(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Dept. of Surgery) | Sudchit Chungpivat(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Veterinary Pathology. Parasitology Unit) | Suvit Gumtorntip(Chulalongkorn University, Bangkok (Thailand). Small Animal Hospital) | Manida Viriyasiri(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Pharmacology) | Wanwisa Wittayarak(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Pharmacology) | Worrawan Sittiweeratam(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Pharmacology) | Sirintorn Yibchok-anun(Chulalongkorn University, Bangkok (Thailand). Faculty of Veterinary Sciences. Department of Pharmacology)
This study compared the efficacy of 2 anthelmintic drugs, a mixture of oxantedl pamoate, pyrantel pamoate and praziquantel (OPP) and a mixture of pyrantel pamoate and praziquantel (PP) against hookworm and whipworm infections in dogs. A group of 13 stray dogs of both sexes and older than 1 year from the Bangkok Metropolitan Authority Compound, were selected for being naturally infected with both hookworms and whipworms. They were divided into 3 groups. The first group of 3 dogs was used as untreated controls. The second group of 5 dogs was treated orally with OPP and the last group of 5 dogs was treated with PP using a single oral dose (10 kg body weight per tablet). After administration, faecal samples from all dogs were examined for parasitic eggs (EPG, eggs per gram) on days 1-7, 14, 21 and 30 using the McMaster Chamber Technique. At the end of the experiment, all dogs were necropsied to look for any remaining worms in the gastrointestinal tract. The efficacy of the drugs was evaluated using the controls as a test sample. The results showed that OPP was highly effective against both hookworms and whipworm with 100 percent clearance, whereas PP was highly effective against hookworms (99.37-100 percent) but less effective against whipworms (78.95 percent).
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