Changes of vital parameters after administration of butorphanol during tiletamine-zolazepam-ketamine-xylazine anaesthesia for joint surgery in miniature pigs
2008
Rauser, P.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Malych Zvirat | Lexmaulova, L.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Malych Zvirat | Srnec, R.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Malych Zvirat | Lorenzova, J.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Malych Zvirat | Kecova, H.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Malych Zvirat | Crha, M.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Malych Zvirat | Fichtel, T.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Malych Zvirat | Novotna, R.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Malych Zvirat | Dvorak, M.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Malych Zvirat | Necas, A.,Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Malych Zvirat
The study compares the effects of butorphanol in pigs undergoing joint surgery in tiletamine-zolazepam-ketamine-xylazine (TKX) anaesthesia. A total of 12 pigs were divided into 2 groups by 6 animals - BUT (anaesthetized with TKX combination and butorphanol) and CON (control group - anaesthetized with TKX combination only). All pigs were sedated with a mix of tiletamin-zolazepam-ketamin-xylazin, put into total anaesthesia using propofol, and connected to an anaesthesiology unit (O2-Air). For 40 min we logged the heart rate (HR), respiratory rate (RR), mean arterial pressure (MAP), haemoglobin saturation by oxygen (SpO2) and end-tidal CO2 concentration (ETCO2) values. Ten minutes after connecting to the devices, the pigs in the BUT group were intravenously administered butorphanol (0.2 mg/kg) in the total volume of 2 mL, or physiological saline in the same volume. The pigs in the BUT group had a lower (p less than 0.05) HR in the 5th, 10th and 25th min, and a lower RR in the 10th, 15th and 20th min. MAP, ETCO2 and SpO2 values did not differ substantially. Butorphanol can thus be identified as a suitable analgesic TKX supplement to anaesthesia of miniature pigs with minimum effect on vital functions.
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