Tissue Concentration of Quercetin, Isoquercitrin and Hyperoside, and Lipid Profile Changes Following 8-Week Feeding of Angelica keiskei Powder in Rats
2007
Choe, K.H. (Kunsan National University, Kunsan, Republic of Korea) | Choe, S.N. (Kunsan National University, Kunsan, Republic of Korea) | Choo, J.J. (Kunsan National University, Kunsan, Republic of Korea) | Lee, J.Y. (Kunsan National University, Kunsan, Republic of Korea) | Kim, J.Y. (Kunsan National University, Kunsan, Republic of Korea) | Kim, J.W. (Kunsan National University, Kunsan, Republic of Korea) | Choi, J.S. (Kunsan National University, Kunsan, Republic of Korea) | Park, K.S. (Kunsan National University, Kunsan, Republic of Korea) | Park, K.H. (Kunsan National University, Kunsan, Republic of Korea), E-mail: [email protected]
In this study, we examined the effects of Angelica keiskei (AK) in rats, in order to evaluate tissue quercetin concentrations and serum lipid profile changes. Dried AK powder was added to a regular chow at a 5% level, and fed for 8 weeks to male rats. AK significantly lowered serum total cholesterol, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol levels, while it increased high-density lipoprotein cholesterol levels. However, AK did not influence serum triglyceride levels. Two antioxidant flavonoids present in AK, quercetin and its glycoside isoquercitrin, were detected in the serum and liver of the rat.
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