Ameliorating effects of yeast glucan with zinc bisglycinate on histological and biochemical changes in gamma-irradiated rats
2008
El-Batal, A.I. (National Center for Radiation Research and Technology, Cairo (Egypt). Dept. of Drug Radiation Research) | Azab, K.H.S.H. (National Center for Radiation Research and Technology, Cairo (Egypt). Dept. of Radiation Biology) | Saada, H.N. (National Center for Radiation Research and Technology, Cairo (Egypt). Dept. of Radiation Biology) | Rezk, R.G. (National Center for Radiation Research and Technology, Cairo (Egypt). Dept. of Radiation Health) | El-Tahawy, N.A. (National Center for Radiation Research and Technology, Cairo (Egypt). Dept. of Radiation Biology)
The present study aimed to examine the radioprotective effect of a nutraceutical supplement of yeast glucan with Zn bisglycinate against histological and biochemical changes induced by gamma-irradiation. Animals received orally in water suspension (65 mg Glucan + 100 mg Zn bisglycinate per kg body weight for 5 consecutive days before irradiation & 7 days during the period of radiation exposure) (2 Gy x 4 delivered every other day). Results revealed that the major part of yeast extract was 1, 3-beta-D-glucan and confirm the existence of chelation in Zn bisglycinate. Histological examinations of different tissues (liver, heart, kidney and testis) showed that administration of the nutraceutical supplement has attenuated radiation-induced damaged and improved tissue architecture. The histological amelioration in the different tissues was accompanied by a remarkable decrease of their lipid peroxide levels. Moreover, the metabolic disorders accompanying tissue damage were significantly ameliorated. Changes in serum aspartate amino transferase (AST), alanine amino transferase (ALT), gamma glutamyl transferase gamma-GT), acid phosphatase (ACP), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) activities, urea, creatinine glucose content and lipid profile were significantly ameliorated, compared to corresponding values in irradiated rats. According to the obtained results 1,3-beta-D-glucan with zinc bisglycinate might be considered a potent nutraceutical supplement with a remarkable radioprotective capacity.
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