The evaluation of the concentrations of methylprednisolone applied intravenously and by iontophoresis in the pig
2009
Djurdjevic, S., Military Medical Academy, Belgrade (Serbia) | Jezdimirovic, M., University of Belgrade, Belgrade (Serbia). Faculty of Veterinary Medicine | Djurovic, A., Military Medical Academy, Belgrade (Serbia) | Dedic, G., Military Medical Academy, Belgrade (Serbia) | Aleksic, N., University of Belgrade, Belgrade (Serbia). Faculty of Veterinary Medicine | Brankovic, N., Faculty of Sports and Physical Education, Nis (Serbia) | Stojiljkovic, S., Faculty of Sports and Physical Edication, Nis (Serbia) | Stojsic, D., Military Medical Academy, Belgrade (Serbia) | Blagojevic, Z., Institute for Orthopaedic Surgery Banjica, Belgrade (Serbia)
The current clinical research on pharmacokinetics of methylprednisolone was performed on male pigs to whom was administered either intravenously or locally, via iontophoresis. The results indicate high quantities of methylprednisolone both in the synovial fluid and hyaline cartilage, the concentrations being significantly higher in animals after iontophoretic application in comparison with the animals treated intravenously. Thus, ionotophoresis was proved a highly advisable clinical means of application of methylprednisolone, especially having in mind the possibility of avoiding systemic adverse effects which are present after parenteral drug administration. In addition, it enables higher therapeutic concentrations of MPSS (methylprednisolone sodium succinate) to be obtained both in the synovial fluid and in hyaline cartilage of the treated inflamed joints.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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