Azinyl sulfides - CXVIII. antimicrobial activity of novel 1-methyl-3-thio-4-aminoquinolinium salts
2010
Zieba, A.,The Medical Univ. of Silesia, Sosnowiec (Poland). Dept. of Organic Chemistry | Wojtyczka, R.D.,The Medical Univ. of Silesia, Sosnowiec (Poland). Dept. of Microbiology | Kepa, M.,The Medical Univ. of Silesia, Sosnowiec (Poland). Dept. of Microbiology | Idzik, D.,The Medical Univ. of Silesia, Sosnowiec (Poland). Dept. of Microbiology
Synthesis and antimicrobial activity of novel 1-methyl-3-alkylthio-4-aminoquinolinium salts 2 and 1-methyl-3-acylthio-4-aminoquinolinium salts 4 are described. Compounds 2 were obtained by reacting 1-methyl-3,4-(dimethylthio)quinolinium chloride 1 with amines and by reacting 1-methyl-4-aminoquinolinium-3-thiolates 3 with alkylating agents. Compounds 4 were obtained by the reaction of 1-methyl-4-aminoquinolinium-3-thiolates 3 with acylating agents. Antimicrobial activity of compounds 2 and 4 was determined using G+ (Staphylococcus aureus, Enterococcus faecalis) and G- (Escherichia coli, Pseudomonas aeruginosa) strains as well as Candida albicans yeast. The compounds show greatest activity against S. aureus, whereas the lowest one against P. aeruginosa.
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