An Acetophenone Derivative, Clavatol, and a Benzodiazepine Alkaloid, Circumdatin A, from the Marine-Derived Fungus Cladosporium
2009
Yang, G.H., Pukyong National University, Busan, Republic of Korea | Nenkep, Viviane N., Pukyong National University, Busan, Republic of Korea | Siwe, Xavier, Pukyong National University, Busan, Republic of Korea | Leutou, Alain S., Pukyong National University, Busan, Republic of Korea | Feng, Zhile, Pukyong National University, Busan, Republic of Korea | Zhang, Dahai, Pukyong National University, Busan, Republic of Korea | Choi, H.D., Dongeui University, Busan, Republic of Korea | Kang, J.S., Pusan National University, Yangsan, Republic of Korea | Son, B.W., Pukyong National University, Busan, Republic of Korea
The crude extract of the mycelium of Cladosporium was found to exhibit antimicrobial activity against the Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. Bioassayguided fractionation of an organic extract led to the isolation of an acetophenone derivative, clavatol (2',4'-dihydroxy-3',5'-dimethylacetophenone) (1), and a benzodiazepine alkaloid, circumdatin A (2). Compound 1 showed moderate antibacterial activity against S. aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus with minimum inhibitory concentration (MIC) values of 62.5, 62.5, 31.0 ㎍/mL, respectively, but compound 2 was inactive. Compounds 1 and 2 exhibited UV-A protection activity with ED∧50 values of 227.0 and 82.0 μM, respectively, indicating that they were more potent than the positive control, oxybenzone (ED∧50 350 μM), a common sunscreen agent.
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