A GHR Polymorphism and Its Associations with Carcass Traits in Hanwoo Cattle
2009
Han, S.H. (Jeju Sub-station, National Institute of Animal Science, RDA, Jeju, Republic of Korea) | Cho, I.C. (National Institute of Animal Science, RDA, Suwon, Republic of Korea) | Kim, J.H. (National Institute of Animal Science, RDA, Suwon, Republic of Korea) | Ko, M.S. (Jeju Sub-station, National Institute of Animal Science, RDA, Jeju, Republic of Korea) | Jeong, H.Y. (Jeju Sub-station, National Institute of Animal Science, RDA, Jeju, Republic of Korea) | Oh, H.S. (Cheju National University, Jeju, Republic of Korea) | Lee, S.S. (Jeju Sub-station, National Institute of Animal Science, RDA, Jeju, Republic of Korea), E-mail: [email protected]
The growth hormone receptor (GHR) is a membrane transmitter for the growth hormone signal transduction pathway that regulates various metabolic activities, including cell growth and expressions of cytokine genes. The presence or absence of a genetic polymorphism for the LINE-1 retroposon in the P1 promoter, which specifically regulates the GIN gene expression in the Ever, was screened by a novel detection method and examined for its relationships with carcass traits in Hanwoo cattle. Hanwoo cattle had taurine type LINE-1 present (allele I) as well as incidine type LINE-1 absent (allele A) promoter sequences. Three genotypes, I/I, I/A and A/A showed frequencies of 49.1, 36.7 and 14.2%, respectively. The effects of allele A were significant on mean differences for final weight, eye muscle area, marbling score and fat color (p less than 0.05), but not for carcass weight, backfat thickness, final meat quality grade or meat color (p greater than 0.05). Most 30-month old Hanwoo steers bearing the LINE-1 absent promoter had whiter fat color, heavier live weight and higher marbling score, reflecting intramuscular fat deposition in M. longissimus dorsi, compared to animals bearing a LINE-1 present promoter. This suggests that a GHR polymorphism could be a potential genetic marker for improving beef production of Hanwoo cattle.
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