Discoid lupus erythematosus (DLE) in a juvenile Alaskan Malamute dog
2009
Kim, H.J., Konkuk University, Seoul, Republic of Korea | Yoo, J.H., Konkuk University, Seoul, Republic of Korea | Kim, J.W., Konkuk University, Seoul, Republic of Korea | Park, C., University of California at Davis, Davis, CA, USA | Lim, C.Y., Konkuk University, Seoul, Republic of Korea | Lee, J.H., Konkuk University, Seoul, Republic of Korea | Quan, Fu-Shi, The Catholic University of Korea, Seoul, Republic of Korea | Park, H.M., Konkuk University, Seoul, Republic of Korea
Discoid lupus erythematosus (DLE) is an immune-mediated skin disease which requires histopathology and immunohistopathology in both dogs and humans. A 10-month-old, intact female Alaskan Malamute presented for depigmentation, swelling, alopecia, erythema, and crusting on the bridge of the nose and the nasal planum. Cytological examination of nasal lesions revealed numerous cocci and neutrophils. Histopathological features included of infiltration of mononuclear cells at the dermoepidermal junction. Direct immunofluorescence tests and immunohistochemistry exhibited positive IgG, IgM, IgA, CD3, CD18, and CD 79a on the epidermal basement membranes and around adnexal glands. This case indicates both T cells and B cells are related to mechanism of canine DLE. This case report describes advanced diagnostic tests and clinical outcome with immume suppressive therapy in a rare juvenile canine DLE case.
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