Rate of free radical peroxidation of lipids, activity of adenylate cyclase and permeability of plasma membrane for Ca2+ ions in cells of peripheral blood of sheep exposed to low-level radiation
2009
Mirzoev, Eh.B. | Kobyalko, V.O., All-Russia Research and Development Inst. of Agricultural Radiology and Agroecology, Kaluga Region (Russian Federation)
The rate of free radical peroxidation of lipids, activity of adenylate cyclase and permeability of plasma membrane for Ca2+ ions in cells of peripheral blood of Precoce sheep exposed to low-level radiation were estimated. Chronic exposure of sheep at doses 0.1 and 0.5 Gr resulted in reduced content of malondialdehyde, diene and triene conjugates and alpha-tocopherol with simultaneous increase in the retinol level in blood plasma. In lymphocytes of peripheral blood of sheep the activity of adenylate cyclase was decreased, and in thrombocytes the phase pattern of changes was observed. The enzyme activity in blood cells stimulated by forskolin and prostaglandid E1 was more pronounced. The estimation of plasma membrane permeability for Ca2+ ions in peripheral blood neutrophils has revealed nonlinear pattern of variations. The rate of intracellular accumulation of Ca2+ ions with regard to the dosage of gamma-radiation was multidirectional. There was an increase in passive plasma membrane permeability for Ca2+ ions in radioresistant erythrocytes. It is concluded that increasing the passive plasma membrane permeability for Ca2+ ions under effect of low-level gamma-radiation indirectly confirm reconstructions of membranes. As a consequence, changing the passive plasma membrane permeability for ions and activity of membrane-connected regulator systems influence the mechanisms of intracellular transmitting of signals
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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