Protective Effects of Loquat (Eriobotrya japonica) Leaves against Ethanol-induced Toxicity in HepG2 Cells Transfected with CYP2E1
2010
Bae, D.H., Chonnam National University, Gwangju, Republic of Korea | You, Y.H., Chonnam National University, Gwangju, Republic of Korea | Yoon, H.G., Yonsei University, Seoul, Republic of Korea | Kim, K.M., Korea Bio Polytechnic College, Nonsan, Republic of Korea | Lee, Y.H., The University of Suwon, Suwon, Republic of Korea | Kim, Y.J., Chonnam National University, Gwangju, Republic of Korea | Baek, H.Y., Korea INS Pharm Research Institute, Hwasun, Republic of Korea | Kim, S.O., Jeonnam Institute of Natural Resources Research, Jangheung, Republic of Korea | Lee, J.M., Kyung Hee University, Yongin, Republic of Korea | Jun, W.J., Chonnam National University, Gwangju, Republic of Korea
Hepatoprotective effects of loquat (Eriobotrya japonica) leaves were investigated in HepG2 cells over-expressing CYP2E1. When compared to cells treated with 200 mM ethanol alone, a concentration-dependent increase in cell viability was observed in the cells pretreated with 40 and 80 ㎍/mL of 5% ethanol extract (EJE) of loquat leaves (23 and 36%, respectively). Also, pretreatment with EJE lead to a decrease in intracellular reactive oxygen species formation and an increase in hepatic antioxidant activity. These results suggest that EJE attenuates oxidative stress by improving antioxidative potentials, which contribute to this herb's protective profile against ethanol-induced toxicity in vitro.
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