The experimental iron disorders of the liver and small intestine
2010
Knipse, G., University of Latvia, Riga (Latvia). Faculty of Medicine. Dept. of Anatomy and Histology | Babarikins, D., Institute of Innovative Biomedical Technologies, Riga (Latvia) | Markovs, J., University of Latvia, Riga (Latvia). Faculty of Medicine. Dept. of Anatomy and Histology | Berzina, N., University of Latvia, Salaspils (Latvia). Inst. of Biology | Gramatniece, A., University of Latvia, Riga (Latvia). Faculty of Medicine. Dept. of Anatomy and Histology
Two feeding studies with rats and cockerels were conducted to evaluate the role of iron deficiency and overload in the morphofunctional changes in the liver and intestine. Administration of an iron – deficient diet to Wistar-Kyoto rats resulted within 20 days in significantly reduced serum iron concentrations, a hypochromic anemia, and increased intestinal villus height but no pronounced effects on cell proliferation was observed. The iron concentration in the liver of iron – deficient rats was found to increase. At the same time, the most common laboratory tests for the detection of liver injury – serum aminotransferases (ASAT and ALAT) were altered. We considered that moderate iron deficiency results in complex systemic disorders, including hypochromic anemia, duodenum mucosal hyperplasia and hepatocellular injury. Our observations emphasize also the importance of vacuolar compartmentalization in controlling iron fluxes in enterocyte and suggest that TRPV1- dependent iron uptake by subapical vesicles may play an important role in metal ion homeostasis of intestinal epithelium.
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