First histological findings in rabbit model of peritoneal dialysis
2010
Stojimirović, B., Clinical Center of Serbia, Belgrade (Serbia) | Jovanović, N., Clinical Center of Serbia, Belgrade (Serbia) | Laušević, Z., Clinical Center of Serbia, Belgrade (Serbia) | Krstić, S., Clinical Center of Serbia, Belgrade (Serbia) | Obradović, M., University of Belgrade, Belgrade (Serbia). School of Medicine | Žunić-Božinovski, S., University of Belgrade, Belgrade (Serbia). School of Medicine
Investigating peritoneal membrane alterations caused by peritoneal dialysis fluid during peritoneal dialysis in humans is still intriguing. That is why the study was aimed to provide rabbit peritoneal tissue samples suitable for histological analyses using a modified non-uremic infusion model of peritoneal dialysis on rabbit. A double-lumen central venous catheter, surgically placed in the peritoneal cavity of adult Chincilla rabbit, was used for daily instillations of peritoneal dialysate. Peritoneal tissue samples were obtained during the catheter placement and removal and analysed by light and transmission electron microscopy. The results of histological examinations showed that this modified non-uremic rabbit model of peritoneal dialysis is suitable for obtaining peritoneal tissue samples for light and transmission electron microscopy examination, and can be used to analyse the effects of different dialysis solutions on rabbit peritoneal membrane.
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