Antifungal activity of polycyclic aromatic hydrocarbons against ligninolytic fungi | Antifungalna aktivnost odabranih policikličnih aromatičnih ugljovodonika prema ligninolitičkim gljivama
2011
Memić, M., Univerzitet u Sarajevu, Sarajevo (Bosnia and Herzegovina). Prirodno–matematički fakultet | Selović, A., Univerzitet u Sarajevu, Sarajevo (Bosnia and Herzegovina). Prirodno–matematički fakultet | Sulejmanović, J., Univerzitet u Sarajevu, Sarajevo (Bosnia and Herzegovina). Prirodno–matematički fakultet
Environmental contamination by polycyclic aromatic hydrocarbons (PAHs) has been causing increasing concern because of their known, or suspected, carcinogenic and mutagenic effects. Polycyclic aromatic hydrocarbons occurring in the environment are usually the result of incomplete combustion of carbon containing materials. The main sources of severe PAHs contamination in soil come from fossil fuels, i.e., production or use of fossil fuels or their products, such as coal tar and creosote. Creosote is used as a wood preservation for railway ties, bridge timbers, pilling and large-sized lumber. It consists mainly of PAHs, phenol and cresol compounds that cause harmful health effects. Research on biodegradation has shown that a special group of microorganisms, the white-rot fungi and brown-rot fungi, has a remarkable potential to degrade PAHs. This paper presents a study of the antifungal activity of 12 selected PAHs against two ligninolytic fungi Hypoxylon fragiforme (white rot) and Coniophora puteana (brown rot). The antifungal activity of PAHs was determined by the disc-diffusion method by measuring the diameter of the zone of inhibition. The results showed that the antifungal activity of the tested PAHs (concentration of 2.5 mmol/L) depends on the their properties such as molar mass, solubility in water, values of log Kow, ionization potential and Henry’s Law constant as well as number of aromatic rings, molecule topology or pattern of ring linkage. Among the 12 investigated PAHs, benzo(k) fluoranthene with five rings, and pyrene with four cyclic condensed benzene rings showed the highest antifungal activity.
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