Preparation of marigold (Calendula officinalis L.) extract using carbon dioxide under pressure and its microencapsulation in the polymer-surfactant systems. [Doctoral dissertation] | Dobijanje ekstrakta nevena (Calendula officinalis L.) ugljendioksidom pod pritiskom i njegovo mikrokapsuliranje u sistemu polimer-površinski aktivna materija. Doktorska disertacija
2010
Popović, L.
The aim of this thesis was to investigate the possibility to incorporate marigold extract (Calendula officinalis), as a pharmacologically active compound, into microcapsules in order to protect them from surrounding medium, improve their activity and enlarge application. Marigold extracts were obtained by means of carbon dioxide-CO2 under subcritical and supercritical conditions. Extraction conditions under which obtained extract has high content of essential oil, responsible for gastrointestinal activity, were determined (200 bar and 40 deg C). Total extract obtained under such conditions was chosen for microcapsule preparation. Application possibility of polymer-surfactant interaction of between non-ionic cellulose derivative-hydroxypropylmethyl cellulose (HPMC) and anionic surfactant –sodium dodecylsulfate (SDS) to microcapsule wall formation was investigated. It was provided that emulsions prepared in the region of pronounced HPMC-SDS interaction, where HPMC/SDS complex is absorbed at the o/w interface, have highest stability and smallest particle mean diameter. Microcapsules were obtained by spray drying of emulsions stabilized with HPMC/SDS complex. The best characteristics have microcapsules obtained in the region of most pronounced interaction. Investigations conducted in this thesis showed that characteristic of polymer/surfactant complexes can be used in microencapsulation of oil as carrier of pharmacologically active compounds.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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