Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine
2011
Spasojević, N., Institute of Nuclear Sciences Vinča, Begrade (Serbia) | Jovanović, P., Institute of Nuclear Sciences Vinča, Begrade (Serbia) | Spasojević-Tišma, V., Institute of Nuclear Sciences Vinča, Begrade (Serbia) | Đelić, N., Faculty of Veterinary Medicine, Belgrade (Serbia) | Dronjak, S., Institute of Nuclear Sciences Vinča, Begrade (Serbia)
It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamineß- hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo. Key words: Antidepressants, catecholamine enzymes, gene expression, atria, ventricles, rats
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