The influence of different formulation factors on physicochemical and biopharmaceutical characteristics of ketoprofen 2,5% gel | Uticaj faktora formulacije na fizičkohemijske i biofarmaceutske karakteristike ketoprofen 2,5% gela
2010
Jončić-Savić, K., Galenika a.d., Beograd (Serbia). Institut za istraživanja i razvoj | Pešić, J., Galenika a.d., Beograd (Serbia). Institut za istraživanja i razvoj | Rajić, M., Galenika a.d., Beograd (Serbia). Institut za istraživanja i razvoj | Lukić, M., Farmaceutski fakultet, Beograd (Serbia) | Jakšić, I., Farmaceutski fakultet, Beograd (Serbia) | Milić, J., Farmaceutski fakultet, Beograd (Serbia) | Vuleta, G., Farmaceutski fakultet, Beograd (Serbia) | Savić, S., Farmaceutski fakultet, Beograd (Serbia)
In recent years there has been a growing interest for the development and characterization of vehicles for active pharmaceutical ingredients (API) for semisolid dosage forms. Considering that research efforts applied on the new APIs are time consuming and costly, one of the approaches for advancement of therapies of skin and mucous tissue diseases or therapies for muscle and joint pain is focused on the modification of the existing formulations and development and characterization of new vehicles for APIs. The aim of this study was to evaluate the effect of variation of different factors of formulation such as type and concentration of gelling agents, concentration of isopropyl alcohol (IPA) as a solvent and as a penetration enhancer, physicochemical properties of the active substance (ketoprofen) obtained from different manufacturers, on properties and stability of hydrophilic gel with 2.5% m/m ketoprofen. Characterization of prepared samples was done through physicochemical, biopharmaceutical investigation and stability testing. Results obtained suggest satisfactory physicochemical stability of investigated samples as well as the formulation factors which have the most effect on physicochemical properties of ketoprofen gel product: the type of gelling agent followed by the concentration of the gelling agent, while the IPA concentration has the least effect (in the investigated range). Comparison of release profiles of the investigated formulations of carbomer gels did not show significant effect of the varied factors (concentration of the gelling agent and IPA) on ketoprofen release.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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