Seroprevalence of hepatitis E among blood donors in Serbia
2012
Petrović, T., Scientific Veterinary Institute Novi Sad, Novi Sad (Serbia) | Lupulović, D., Scientific Veterinary Institute Novi Sad, Novi Sad (Serbia) | Vojvodić, S., Institute for Blood Transfusion of Vojvodina, Novi Sad (Serbia) | Jiménez de Oya, N., INIA, Madrid (Spain). Department of Biotechnology | Escribano-Romero, E., INIA, Madrid (Spain). Department of Biotechnology | Blázquez, A.B., INIA, Madrid (Spain). Department of Biotechnology | Lazić, S., Scientific Veterinary Institute Novi Sad, Novi Sad (Serbia) | Saiz, J.C., INIA, Madrid (Spain). Department of Biotechnology
Hepatitis E virus (HEV), an enterically transmitted pathogen, is one of the major causes of acute hepatitis in humans, being responsible for outbreaks and epidemics in regions with sub-optimal sanitary conditions, especially in some parts of Asia, Africa, Mexico and Middle East, in many of which it is endemic. In the present study, the prevalence of anti-HEV IgG antibodies among blood donors in Serbia was investigated by means of an ELISA based on a recombinant open reading frame 2 protein of HEV genotype3. A total of 200 serum samples from blood donors of different age, sex and occupations, which live in Novi Sad (22/11.06%) and surrounding villages (177/88.94%) in the Vojvodina Province, in the northern part of Serbia were examined. We found that 30 (15%) of the 200 analyzed blood donors tested positive in the ELISA test, and that the prevalence increases with age. Anti-HEV IgG positive serum samples had an average P/N of 4.45 +/- 1.95 (range 2.5-9.58). These results indicate that HEV infection is not just occasionally present in human population in Serbia. Further investigation of HEV infection in Serbia is needed for the estimation of the real prevalence and possible health efects on the human population.
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