Prevalence of qacA/B gene in methicilin-resistant Staphylococcus aureus | Zastupljenost gena qacA/B kod meticilin-rezistentnih sojeva Staphylococcus aureus
2011
Opačić, D., Vojnomedicinska akademija, Beograd (Serbia) | Lepšanović, Z., Vojnomedicinska akademija, Beograd (Serbia) | Sbutega-Milošević, G., Medicinski fakultet, Beograd (Serbia) | Stajković, N., Vojnomedicinska akademija, Beograd (Serbia)
Many cationic antimicrobial agents (chlorhexidine gluconate, benzalkonium chloride) are used in the prevention of nosocomial infections caused by methicilin-resistant Staphylococcus aureus (MRSA) strains. However, overuse of biocide (antiseptics and disinfectants) agents has led to the emergence of MRSA with decreased biocide susceptibility and these strains have been isolated from clinical samples. The purpose of the present study was to investigate the prevalence of biocide resistant qacA/B gene in clinical strains of methicilin-resistant and –susceptible (MSSA) S. aureus and to determine whether there is a significant difference between MRSA and MSSA strains. A total of 100 randomly selected MRSA and MSSA strains were investigated between 2007 and 2009. By polymerase chain reaction (PCR), qacA/B gene was deteted in 17 of the total of 100 strains (17%): in 16 out of the 50 MRSA (32%) and in one out of 50 MSSA (2%) strains, p is less than 0.000. The qacA/B genes have become a major cationic resistance genes in MRSA, hence, their prevalence in the hospital environment must be considered. their survival might be due either to selective pressure imposed by use of cationic antimicrobial agents or due to cross-resistance and co-resistance between these agents and antibiotics. Epidemiological information on biocide susceptibility and the distribution of qacA/B resistance genes is useful for nosocomial infection control.
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