Bendiocarb and potential oxidative injury of an organism
2011
Žeňuchová, A., University of Veterinary Medicine and Pharmacy in Košice (Slovak Republic) | Sobeková, A.
This study investigated the potential influence of bendiocarb on the antioxidative enzyme system of the liver and kidneys in female rabbits following administration of 5 mg per kg b. w. for 30 days. The specific activity of superoxide dismutase (SOD) and catalase (CAT) in the liver remained unchanged but the activity of glutathion peroxidase(GSH Px) was inhibited significantly on day 3. The kidneys showed significantly decreased specific activity of SOD from day 10 of the experiment. No significant changes in the activity of CAT and GSH Px were observed in any experimental group. The inhibition of activity of some enzymes could result from the accumulation of reactive oxygen species (RO S). The changes observed in the antioxidative enzyme system confirmed the development of RO S after exposure to bendiocarb. The oxidative damage to the investigated organs was confirmed by the increased levels of thiobarbituric acid reactive substances TBARS), an indicator of lipid damage.
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