Allometric analysis of antibacterial drugs in avian species
2012
Lashev, L., Thracian University, Stara Zagora (Bulgaria) | Haritova, M., Thracian University, Stara Zagora (Bulgaria)
The purpose of this study was to examine the allometric relationships of fluoroquinolones, penicillins, aminoglycosides, sulfonamides, tetracyclines and florfenicol in bird species using pharmacokinetic data from the literature. The parameters of interest - half-life, volume of distribution, and total body clearance were correlated as a function of body weight applying an allometric approach - Y=aWb. Values of the coeficient a and the exponent b were close to the theorethical values for the clearance and volume of distribution of most drugs, except for sulfadimidine, tobramycin and apramycin. The elimination half-life was relatively independent of body mass for penicillins, pefloxacin, doxycycline and trimethoprim. Results of the analysis suggest that allometric scaling can be used as a tool for predicting pharmacokinetic parameters for most drugs in avian species. The predictive power is stronger, when only data for bird species are included, in comparison to simultaneous allometric scaling of the data for avian and mammalian species.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institute of Agricultural Economics