The semi-modified diets as antioxidants, hypolipidemic and hypocholesterolemic agents

This study was carried out to evaluate the effects of unpeeled lentil seeds (legume), apple (fruit) and parsley (vegetable) in semi-modified diets on lipid fraction of hyperlipidemic and hypercholesterolemic male albino rats. The investigation was done with semi-modified diets of unpeeled lentil seeds, dried apple and dried parsley as well as their mixtures (1: 1: 1) to evaluate their effects as hypolipidemic agents which amounted 10% of the diets at the expense of starch. Composition of the apple, parsley and unpeeled lentil seeds was estimated on dry matter. The results observed that three used diets amounted good values of protein (especially unpeeled lentil) crude fiber and phenolic compounds (espicially apple and parsley). The HPLC analysis of the three methanolic extracts of unpeeled lentil, apple and parsley for the phenolic compounds showed presence of about 23 compounds varying in their levels in the extracts. The obtained results showed that unpeeled lentil seeds as well as dried apple and parsley semi-modified diets generally improved the clinical blood status. [Blood picture (RBCs, WBCs and Hb), lipid fraction such as total lipid, cholesterol and trigIycerides, as well as HDL-C, LDL-C and VLDL-C] also the treatment alleviated the risk factor of the hyperlipidemie rats. Liver function (AST, ALT and ALP activity as well as bilirubin) and kidneys function (uric acid, urea and creatinine), total protein and its fractions (albumin and globulin), tipids peroxidation and antioxidative enzymes activity (SOD and catalase) were readjusted around the normal values in hyperlipidemic and hypercholesterolemic rats by the improvements of the present liportopic factors and antioxidative agents of unpeeled lentil, apple and parsley by which hyperlipidemic and hypercholesterolemic were alleviated. In connection, the semi-modified mixture diet gave the best clinical effects concerning biological studies. It means that mixture produced such synergetic effects which used semi modified diets of unpeeled lentil, apple and parsley alone.