Antimicrobial Activity of Korean Herbal Complex Extract and Clay Mineral Mixture against Escherichia coli O157:H7
2010
Lee, Y.O., Senong Co., Ltd., Changwon, Republic of Korea | Jung, W.C., Gyeongsang National University, Jinju, Republic of Korea | Cha, C.N., Gyeongsang National University, Jinju, Republic of Korea | Kim, G.S., Gyeongsang National University, Jinju, Republic of Korea | Lee, Y.E., Gyeongsang National University, Jinju, Republic of Korea | Kim, S., Gyeongsang National University, Jinju, Republic of Korea | Lee, H.J., Gyeongsang National University, Jinju, Republic of Korea
The present study was evaluated the antibacterial effect of the combination of Coptidis rhizoma, Lonicerae Flos, and Paeonia japonica (1:1:1) extracts (CLP1000). Also, the effectiveness of CLP1000, dioctahedral smectite (DHS), and the combination of CLP1000 and DHS (CLPS1000) against E. coli O157:H7 infection was studied using ICR female mice. During the incubation period, the dose of 10% and 20% CLP1000 were inhibited the growth of E. coli O157:H7 by 30% and 47%, respectively. For 7 days after single challenge with E. coli O157:H7, forty female ICR mice were divided into four experimental groups which were orally administered with saline, 10% CLP1000, 10% DHS, and 10% CLPS1000, respectively. On the 3rd day, the number of E. coli O157:H7 in mouse feces was significantly decreased by administration of CLP1000 (p less than 0.05), DHS (p less than 0.05) and CLPS1000 (p less than 0.001). On the 7th day, CLP1000 (p less than 0.05) and CLPS1000 (p less than 0.001) administration significantly decreased the number of E. coli O157:H7. According to the results of the present study, administration of CLPS1000 to mice can reduce the severity of E. coli O157:H7 infection. Also, it is suggested that CLPS100 represents a good candidate for the treatment of enteric infections in domestic animals.
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