Long-Term Exposure of Sildenafil Citrate on Sperm Parameters in Rat
2011
Suresh, Sekar, University of Madras, Taramani Campus, Chennai, India | Prithiviraj, Elumali, University of Madras, Taramani Campus, Chennai, India | Venkatalakshmi, Nagella, University of Madras, Taramani Campus, Chennai, India | Ganesh, Mohanraj Karthik, University of Madras, Taramani Campus, Chennai, India | Ganesh, Lakshmanan, University of Madras, Taramani Campus, Chennai, India | Lee, H.J., National Institute of Animal Science, RDA, Suwon, Republic of Korea | Prakash, Seppan, University of Madras, Taramani Campus, Chennai, India
Sildenafil citrate (SIL) a phosphodiesterase 5 inhibitor (PDE5I) has been used for long time as a first line oral drug for erectile dysfunction. Though it has beneficial effects on erectile organ it also has some adverse effects in other cells and/or tissues related to reproductive system when exposed to longer duration. The objective of the present study is to evaluate the long term effect of SIL on sperm parameters in Wistar albino rat. The animals are divided into two groups, for group Ⅰ - rats were treated with saline (vehicle alone) and group - Ⅱ oral administration of 5 mg/kg b.w. of SIL was administrated orally once in a day for 120 days. At the end of the trial period animals were sacrificed and epididymal sperm were subjected to various analysis. Results showed significant reduction in sperm count, motility, viability and morphologically intact sperm in long term PDE5I exposed animals when compared to control. Acrosomal status and fertility test also showed significant reduction in long term PDE5I exposed animals. The present study clearly indicated that long term SIL has shown to induce alteration in sperm quality and quantity, leading to decline in fertility rate. Indicate that SIL impinge on spermatogenesis as well as epididymal function. Understanding the molecular down-stream events involved in long-term exposure to PDE5 inhibitor can be valuable to supervise on related infertility issues and to suggest corrective measures.
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