Enhancement of the Stability and Solubility of Prodigiosin Using β-Cyclodextrin in Seawater
2012
Park, H.Y., Korea Polar Research Institute, KORDI, Incheon, Republic of Korea | Kim, T.K., Korea Polar Research Institute, KORDI, Incheon, Republic of Korea | Han, S.J., Korea Polar Research Institute, KORDI, Incheon, Republic of Korea | Yim, J.H., Korea Polar Research Institute, KORDI, Incheon, Republic of Korea
This research was to examine the effects of various cyclodextrins on the solubility and stability of prodigiosin in seawater. Among them, β-cyclodextrin was found to have the best efficiency and formation of the inclusion complex was saturated when prodigiosin and β-cyclodextrin were mixed in a ratio of 1:8 and shaken at 25℃ and pH 8.0 for 6 h. The maximum algicidal activity against Chattonella antiqua using the inclusion complex stored at 4℃ for 5 weeks of culture was obtained, 52.28±3.41%, which was about 5.0 fold higher than that of control. Our results suggest that inclusion complexes of prodigiosin and β-cyclodextrin could serve as effective algicidal agents.
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