Toxico-pathological effects of parenteral administration of gentamicin in growing broilers
2013
Javed, U. (University of Agriculture, Faisalabad (Pakistan). Dept. of Pathology) | Khan, M.Z. (University of Agriculture, Faisalabad (Pakistan). Dept. of Pathology) | Saleemi, M.K. (University of Agriculture, Faisalabad (Pakistan). Dept. of Pathology) | Khan, A. (University of Agriculture, Faisalabad (Pakistan). Dept. of Pathology) | Javed, I. (University of Agriculture, Faisalabad (Pakistan). Dept. of Physiology and Pharmacology) | Rafique, S. (Pakistan Agricultural Research Council, Islamabad (Pakistan). Animal Sciences Div.)
The present study was designed to investigate the toxicopathological effects induced by intramuscular administration of gentamicin in growing broilers. A total of 180 broiler chicks at four weeks of age were divided into 16 groups and each group was administered a single intramuscular injection of gentamicin varying from 0 to 120 mg/kg body weight. Mortality was 100% in the groups receiving gentamicin 70 mg/kg and above. Feed intake and body weight of gentamicin administered groups was lower than control. The birds administered 0, 10 and 20 mg/kg gentamicin did not exhibit any clinical signs, while those in higher dose groups exhibited depression, sitting on hocks, lack of interest in feed, increased water intake, watery diarrhea and emaciation. Hemorrhagic and swollen kidneys bulging out from bony socket and mild swollen liver with discolored areas were consistent gross findings. Microscopically, kidneys showed severe congestion and tubular necrosis. Total serum protein and albumen was significantly lower in groups receiving higher doses of gentamicin as compared with control. Serum ALT and creatinine values were higher in gentamicin groups as compared with 0 and 10 mg/kg groups indicating nephrotoxic and hepatotoxic effects. It is concluded that gentamicin at higher doses resulted in poor growth and severe nephrotoxic and hepatotoxic effects.
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