A generalized caprine-like hypoplasia syndrome is localized within a 6-cM interval on bovine chromosome 13 in the Montbéliarde breed

Duchesne , Amandine
        INRA
        , Jouy-En-Josas .
         UR 0339 Génétique Biochimique et Cytogénétique; Manciaux , L.
        .; Gautier , Mathieu
        INRA
        , Jouy-En-Josas .
         UR 0339 Génétique Biochimique et Cytogénétique; Floriot , Sandrine
        INRA
        , Jouy-En-Josas .
         UR 0339 Génétique Biochimique et Cytogénétique; Grohs , Cecile
        INRA
        , Jouy-En-Josas .
         UR 0339 Génétique Biochimique et Cytogénétique; Fritz , S.
        .; Druet , Tom
        INRA
        , Jouy-En-Josas .
         UR 0337 Station de Génétique Quantitative et Appliquée; Schelcher , Francois
        INRA
        , Toulouse .
         UMR 1225 Interactions hôtes-agents pathogènes; Ducos , Alain
        INRA
        , Auzeville .
         UR 0631 Station d'Amélioration Génétique des Animaux; Eggen , Andre
        INRA
        , Jouy-En-Josas .
         UR 0339 Génétique Biochimique et Cytogénétique

A generalized caprine-like hypoplasia syndrome is localized within a 6-cM interval on bovine chromosome 13 in the Montbéliarde breed

2008

Duchesne , Amandine (INRA , Jouy-En-Josas (France). UR 0339 Génétique Biochimique et Cytogénétique) | Manciaux , L. (Centre Européen d'Informatique et d'Automation du Doubs et du Territoire de Belfort, Roulans(France).) | Gautier , Mathieu (INRA , Jouy-En-Josas (France). UR 0339 Génétique Biochimique et Cytogénétique) | Floriot , Sandrine (INRA , Jouy-En-Josas (France). UR 0339 Génétique Biochimique et Cytogénétique) | Grohs , Cecile (INRA , Jouy-En-Josas (France). UR 0339 Génétique Biochimique et Cytogénétique) | Fritz , S. (Union Nationale des Coopératives Agricoles d'Elevage et d'Insémination Animale, Paris(France).) | Druet , Tom (INRA , Jouy-En-Josas (France). UR 0337 Station de Génétique Quantitative et Appliquée) | Schelcher , Francois (INRA , Toulouse (France). UMR 1225 Interactions hôtes-agents pathogènes) | Ducos , Alain (INRA , Auzeville (France). UR 0631 Station d'Amélioration Génétique des Animaux) | Eggen , Andre (INRA , Jouy-En-Josas (France). UR 0339 Génétique Biochimique et Cytogénétique)

Summary Caprine-like Generalized Hypoplasia Syndrome (or SHGC) is a new hereditary disorder described in the Montbe´liarde breed. We report here the characterization of this new disease, based on the visual examination of animals affected by SHGC, and on physiological and biochemical studies undertaken on samples of both SHGC and normal animals. Biological samples for more than 150 affected calves and their parents have been collected over the past 4 years within the framework of the Bovine Genetic Disease Observatory. First, pedigree analyses showed that the mode of inheritance is most probably autosomal recessive. Then, a genome scan with 113 animals and 140 microsatellite markers revealed a single locus within a 35-cM region on bovine chromosome 13. Genotypes of 261 animals for 18 new microsatellite markers from the region confirmed the localization of the disorder to a 6-cM interval. Finally, based on the analysis of haplotypes in 463 Montbe´liarde sires, we estimated the frequency of the SHGC mutated allele in the population and could propose a strategy for the systematic eradication of this disorder in the near future.

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