Professional exposure to goats increases the risk of pneumonic-type lung adenocarcinoma: results of the IFCT-0504-Epidemio study
2012
Lutringer-Magnin , Delphine (Hospices Civils de LyonUniversité de Lyon 1Centre National de la Recherche Scientifique, LyonLyonLyon(France). UMR LBBE Laboratoire de Biométrie et Biologie Evolutive) | Girard , Nicolas (Hospices Civils de LyonUniversité de Lyon 1Institut National de la Recherche Agronomique, LyonLyonLyon(France). UMR 0754 RPC Rétrovirus et Pathologie Comparée) | Cadranel , Jacques (Assistance Publique - Hôpitaux de Paris, Paris(France). Hôpital Tenon, Service de Pneumologie) | Leroux , Caroline (INRA , Lyon (France). UMR 0754 Rétrovirus et Pathologie Comparée) | Quoix , Elisabeth (Centre Hospitalier Universitaire de Strasbourg, Strasbourg(France). Hôpital Hautepierre, Service Pneumologie) | Cottin , Vincent (INRA , Lyon (France). UMR 0754 Rétrovirus et Pathologie Comparée) | Del Signore , Corinne (Université de Lyon 1Centre National de la Recherche Scientifique, LyonLyon(France). UMR LBBE Laboratoire de Biométrie et Biologie Evolutive) | Lebitasy , Marie-Paule (Intergroupe Français de Cancérologie Thoracique, Paris(France).) | Cordier , Geneviève (INRA , Lyon (France). UMR 0754 Rétrovirus et Pathologie Comparée) | Vanhems , Philippe (Hospices Civils de LyonUniversité de Lyon 1Centre National de la Recherche Scientifique, LyonLyonLyon(France). UMR LBBE Laboratoire de Biométrie et Biologie Evolutive) | Mornex , Jean-Francois (INRA , Lyon (France). UMR 0754 Rétrovirus et Pathologie Comparée)
Pneumonic-type lung adenocarcinoma (P-ADC) represents a distinct subset of lung cancer with specific clinical, radiological, and pathological features. Given the weak association with tobacco-smoking and the striking similarities with jaagsiekte sheep retrovirus (JSRV)-induced ovine pulmonary adenocarcinoma, it has been suggested that a zoonotic viral agent infecting pulmonary cells may predispose to P-ADC in humans. Our objective was to explore whether exposure to domestic small ruminants may represent a risk factor for P-ADC. We performed a multicenter case-control study recruiting patients with P-ADC as cases and patients with non-P-ADC non-small cell lung cancer as controls. A dedicated 356-item questionnaire was built to evaluate exposure to livestock. A total of 44 cases and 132 controls were included. At multivariate analysis, P-ADC was significantly more associated with female gender (Odds-ratio (OR) = 3.23, 95% confidence interval (CI): 1.32-7.87, p = 0.010), never-smoker status (OR = 3.57, 95% CI: 1.27-10.00, p = 0.015), personal history of extra-thoracic cancer before P-ADC diagnosis (OR = 3.43, 95% CI: 1.10-10.72, p = 0.034), and professional exposure to goats (OR = 5.09, 95% CI: 1.05-24.69, p = 0.043), as compared to other subtypes of lung cancer. This case-control suggests a link between professional exposure to goats and P-ADC, and prompts for further epidemiological evaluation of potential environmental risk factors for P-ADC.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique