Bioavailability of Fe, Cu, Zn and antioxidant defence in anemic rat supplemented with a mixture of heme/non-heme Fe
2013
García, Y., Bioproducts National Center, Mayabeque (Cuba). Laboratory of Antianemic Products | Díaz-Castro, J., Bioproducts National Center, Mayabeque (Cuba). Laboratory of Antianemic Products | López-Aliaga, I., Bioproducts National Center, Mayabeque (Cuba). Laboratory of Antianemic Products | Alférez, M. J. M., Bioproducts National Center, Mayabeque (Cuba). Laboratory of Antianemic Products | Ramos, A., Bioproducts National Center, Mayabeque (Cuba). Laboratory of Antianemic Products | Campos, M. S., Bioproducts National Center, Mayabeque (Cuba). Laboratory of Antianemic Products
Scarce information is available about the recovery of anemia with different iron (Fe) sources on enzymatic antioxidant defence; therefore the current study was designed to assess its effect on utilization of Fe, Cu and Zn and antioxidant defence in liver, erythrocytes, duodenal mucosa and plasma. Weanling female rat were divided in two groups: a control group (n = 10) receiving a normal Fe diet with FeSO4 (45.73 mg per kg) and an anemic group (n = 20) receiving a low-Fe diet (6.92 mg per kg) for 45 days. For the next thirty days, the anemic rats were fed with a normal Fe diet or with a mixture of heme/non-heme Fe (1 mg of Fe of hydrolysed bovine blood, honey and propolis, and 20 mg FeSO4 for 27.92 mg per kg of Fe diet). The anemic group supplemented with the mixture of heme/non-heme Fe showed a positive hematological recovery and the same utilization of the minerals as the group supplemented with FeSO4 only. This group also featured a better balance of antioxidant enzymes. The recovery of anemia with the mixture of heme/non-heme could be considered an alternative therapy to palliate the Fe-deficiency and to reduce the side effects of the classical supplements.
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