Protective effects of a mineral aqueous solution on toxicity in mouse liver and kidney
2013
Park, I.J., Chonbuk National University, Jeonju, Republic of Korea | Cha, S.Y., Chonbuk National University, Jeonju, Republic of Korea | Kang, M., Chonbuk National University, Jeonju, Republic of Korea | So, Y.S., Chonbuk National University, Jeonju, Republic of Korea | Bahng, J.Y., Chonbuk National University, Jeonju, Republic of Korea | Jang, H.K., Chonbuk National University, Jeonju, Republic of Korea
We demonstrated that a mineral aqueous solution (MAS) administered to mice functionally and histologically protected against cisplatin-induced acute renal failure (ARF) and CCl4-induced acute liver failure (ALF). In ARF model, 0.4 and 0.2% MAS decreased mortality and the serum concentrations of blood urea nitrogen (BUN) and creatine in mice. Additionally, 0.4 and 0.2% MAS reduced contraction of distal convoluted tubules and suppressed expression of the proinflammatory cytokines interlukein-6 (IL-6) and tumor necrosis factor (TNF-α) in the kidney. In ALF model, 0.4 and 0.2% MAS decreased serum concentrations of alanine aminotransferase and aspartate aminotransferase in mice. Additionally, 0.4 and 0.2% MAS reduced necrotic areas and suppressed expression of IL-6 and TNF-α in the liver. These results indicate that a MAS might have protective effects against ARF and ALF.
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