Anti-inflammatory Effect of Allium hookeri Root Methanol Extract in LPS-induced RAW264.7 Cells
2012
Kim, C.H., World Institute of Kimchi, Gwangju, Republic of Korea | Lee, M.A., World Institute of Kimchi, Gwangju, Republic of Korea | Kim, T.W., World Institute of Kimchi, Gwangju, Republic of Korea | Jang, J.Y., World Institute of Kimchi, Gwangju, Republic of Korea | Kim, H.J., World Institute of Kimchi, Gwangju, Republic of Korea
Allium hookeri, a member of the onion family, has long been mainly cultivated for food and medicinal use in Southeast Asia countries owing to its various biological properties. However, no studies of the anti-inflammatory effects of A. hookeri extracts have been conducted to date. Therefore, this study was investigated the potential of the methanol extract of A. hookeri to suppress the inflammation in lipopolysaccharide (LPS)-induced mouse macrophage RAW264.7 cells. This study was performed on macrophage cells that were pretreated with 0~500 ㎍/mL of methanol extract of A. hookeri root prior to LPS treatment. Treatment with methanol extract of A. hookeri root significantly inhibited LPS-induced nitric oxide formation in dose-dependent manner. Treatment of A. hookeri root also significantly decreased LPS-induced TNF-α and IL-6 production. The results of this study provide new evidence of the anti-inflammatory properties of A. hookeri and indicate that it may have a potential therapeutic use for the prevention and treatment of macrophage derived chronic immune diseases.
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