Screening of Different Leaf Extracts of Cassia fistula Linn for Investigation of Hypolipidemic Activity in Two Different Rat Models

Guruprasad V., Arvind Gavali College of Pharmacy; Kuntal, Krupanidhi College of Pharmacy; John Wilking, University of Malaya

Screening of Different Leaf Extracts of Cassia fistula Linn for Investigation of Hypolipidemic Activity in Two Different Rat Models

2013

Guruprasad V., Arvind Gavali College of Pharmacy | Kuntal, Krupanidhi College of Pharmacy | John Wilking, University of Malaya

The present investigation was carried out to evaluate the hypolipidemic activity of methanolic and aqueous leaf extracts of Cassia fistula (CF) Linn (Family: Fabaceae) on atherogenic diet (2% cholesterol, 1% Choline Chloride and 2% Lard) induced Male Sprauge-Dawley rats for the period of 21 days. The rats receiving the treatment with leaf methanol and aqueous extract of CF showed significant (P < 0.001) reduction in total cholesterol (TC), triglycerides (TG), High density lipoprotein (HDL), lipid peroxidation (LPO) and other parameters at dose dependent manner but the effect was less than the standard drug Atorvastatin. The results revealed the effectiveness of CF plant against hyperlipidemic activity.

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