Antibiotic susceptibility of Brachyspira hyodysenteriae isolates from Czech swine farms: a 10-year follow-up study
2014
Prasek, J., University of Veterinary and Pharmaceutical Sciences, Brno (Czech Republic). Institute of Infectious Diseases and Microbiology | Sperling, D., University of Veterinary and Pharmaceutical Sciences, Brno (Czech Republic). Ruminant and Swine Clinic | Lobova, D., University of Veterinary and Pharmaceutical Sciences, Brno (Czech Republic). Institute of Infectious Diseases and Microbiology | Smola, J., University of Veterinary and Pharmaceutical Sciences, Brno (Czech Republic). Ruminant and Swine Clinic | Cizek, A., University of Veterinary and Pharmaceutical Sciences, Brno (Czech Republic). Institute of Infectious Diseases and Microbiology
Brachyspira hyodysenteriae is the causative agent of swine dysentery. Loss of clinical efficacy of some antimicrobial agents authorized for treating swine dysentery was observed on certain Czech pig farms. The aim of the present study was to evaluate the antimicrobial sensitivity of six antibiotics using a set of 202 randomly selected B. hyodysenteriae isolates obtained from farms in the Czech Republic between years 1997 and 2006. Minimum inhibitory concentration of antibiotics tylosin, lincomycin, tylvalosin, chlortetracyclin, tiamulin and valnemulin were tested, using an agar dilution method. All antibiotics tested showed an increase in minimal inhibitory concentrations. Continual decrease in susceptibility of B. hyodysenteriae isolates to tiamulin and valnemulin was observed. Multiresistant B. hyodysenteriae were isolated more frequently in the past years. Only a careful use of antibiotics can ensure their efficacy, especially in case of pleuromutilins, in the strategic therapy of swine dysentery. This rare study demonstrates the minimal inhibitory concentration changes of selected antidysenterics among Czech isolates of Brachyspira hyodysenteriae during a ten-year period.
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